Abstract
The renal vasoconstrictor response to graded (0.2 to 3.0 Hz, 20V, 1 msec) direct electrical renal nerve stimulation (RNS) was studied in 9 chronically catheterized fetal (F) lambs (130-142 days gestation; term 145 days) and 3 adult (A) sheep. Changes in renal blood flow (RBF) were monitored using a doppler flow-meter. During RNS, RBF (r=-0.98) decreased and renal vascular resistance (RVR) (r=0.98) increased in a dose-response relation in F and A. Following administration of phentolamine, a rise in RBF (+57% at 1.0 Hz) and a decrease in RVR (-32% at 1 Hz) were observed in F; these changes were not completely blocked with propranolol. At low frequency ( 0.4 Hz) of RNS, % changes in RBF and RVR were significantly higher in F than in A.
(*for p<0.05 when F compared to A) In summary these results demonstrate that during fetal life 1) renal hemodynamics seems to be more sensitive to low frequency RNS than in A; 2) renal vasoconstriction following RNS is dependent on α adrenoceptors; and 3) renal vasodilation produced by RNS during α-blockade is not fully dependent on activation of β-adrenoceptors.
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Robillard, J., Nakamura, K., McWeeny, O. et al. 1625 RENAL NEUROADRENERGIC TRANSMISSION DURING FETAL LIFE. Pediatr Res 19, 381 (1985). https://doi.org/10.1203/00006450-198504000-01649
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DOI: https://doi.org/10.1203/00006450-198504000-01649
