Abstract
To evaluate the long term effects of a 50% reduction in nephron population, we studied male Sprague-Dawley rats weight (BWT) 250±20 gm. Animals were subjected to either a sham operation (S) or right nephrectomy (N). Animals were maintaine on standard lab chow, Intra-arterial blood pressure (B.P.). glomerular filteration rate (GFR) and renal plasma flow (RPF) were measured at 4, 8 and 12 months (Mo.). Animals were then sacrificed, left kidney (LK) weighed and processed for histolog.
Results: (Mean ± S.D.* = p<.05)
No morphologic changes were noted in 4 and 8 mo. S and N animals. Twelve mo. S rats showed 0-2%, segmental glomerulosclerosis. Twelve mo. N rats showed Mean 13%, segmental glomerulosclerosis. Our study shows that in the male rat, a 50% reduction in renal mass leads to functional and morphological damage to the contralateral kidney over a one year period.
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Tejani, A., Lancman, I. & Finberg, L. 1642 LONGITUDINAL STUDY OF RENAL FUNCTION AND MORPHOLOGY IN UNI-NEPHRECTOMIZED RATS. Pediatr Res 19, 384 (1985). https://doi.org/10.1203/00006450-198504000-01666
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DOI: https://doi.org/10.1203/00006450-198504000-01666
