Abstract
To study the route of iron removal by D in an anephric, hemodialyzed, iron-overloaded adolescent we performed iron-balance studies before and after D infusion on 2 separate occasions. Study #1 lasted 5 days and included 2 dialyses after D infusion. Study #2 lasted 4 days and included 1 dialysis after D infusion. Following baseline dialysis, carmen red was given as a stool marker and D was infused (2g IV, over 4 hrs). Carmen red was given again at the end of each study and all stool was collected between the markers. D was infused only once in each study. Dietary iron averaged 7.2 mg per day.
Average post p fecal iron in both studies was 22.0 mg/day, but study #2 showed that the majority was excreted during the 2 days following D infusion. Iron removal by dialysis was minimal compared with the fecal route. Our data demonstrate that D effectively removes iron when infused after dialysis and that stool is the principal route of iron removal.
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Woodhead, J., Weismann, D. & de Alercon, P. 1655 IRON BALANCE IN A DEFEROXAMINE (D) TREATED HEMODIALYSIS PATIENT. Pediatr Res 19, 386 (1985). https://doi.org/10.1203/00006450-198504000-01679
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DOI: https://doi.org/10.1203/00006450-198504000-01679
