Abstract
Premature lambs with RDS have an increased leak of intra-vascular protein into their lungs. We studied 12 lambs to determine the relationship between this protein leak and ventilation. A balloon catheter within a major bronchus was used to protect an area of lung from ventilation since birth in 6 lambs (G1) and after 2 hrs of ventilation in 6 lambs (G2). The lambs were ventilated to maintain normal pCO2 values. At 3 hrs, 125I-albumin was injected intraarterially to measure the protein leak, and at 2 and 4 hrs radiolabeled microspheres were injected into the right ventricle to assess pulmonary blood flow (PBF) distribution. Three min prior to sacrifice 131I-albumin was injected and used to correct for intravascular blood within the lung pieces. At 4 hrs the lambs were sacrificed, the balloon protected areas were separated from the remaining aerated lung, and the lungs were divided into ∼ 60 1 g pieces. The results for the balloon protected areas as % of the total lung are:
An area of lung protected since birth from inflation or baro-trauma had the same magnitude of protein leak as lung that was subjected to ventilation, despite a reduction in blood flow to the protected area. We postulate that circulating vasoactive agents, and not barotrauma, may be a major cause of the increased protein leak seen in RDS.
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Berry, D., Jobe, A. & Ikeqami, M. 1727 DIFFUSE PROTEIN LEAK IN PREMATURE LAMB LUNGS DOES NOT CORRELATE WITH VENTILATION. Pediatr Res 19, 398 (1985). https://doi.org/10.1203/00006450-198504000-01745
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DOI: https://doi.org/10.1203/00006450-198504000-01745
