Abstract
Cilia are essential for the proper maintenance of the respiratory tract. Inhaled drugs are frequently used in the treatment of respiratory disorders and have been shown not to alter ciliary structure. Their effect on ciliary motility has not been adequately studied. In the present study, the effect of various inhaled drugs on the duration of cilia motility was examined using specimens of rabbit trachea. All specimens were studied at room temperature via light microscopy with control samples analyzed concurrently. One drop of the specified drug was placed on the trachea and the duration of ciliary beat was monitored. The following results were obtained:
All drug effects were reversible with washings of normal saline. The wide ranges of cessation time were thought to be due to tissue variation or to mucus on the tissue specimen causing decreased drug penetration. Mucomyst most rapidly effected the cilia. Nasalcrom increased the initial gross frequency of motility to greater than that of matched controls; however, early cessation was still evident. Correlations will be made with electron micrographic findings and in vivo functional studies. These effects should be kept in mind when prescribing inhaled drugs for patients.
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gowen, M., Spock, A. 1768 THE EFFECT OF INHALED DRUGS UPON CILIA MOTILITY. Pediatr Res 19, 405 (1985). https://doi.org/10.1203/00006450-198504000-01786
Issue date:
DOI: https://doi.org/10.1203/00006450-198504000-01786
