Abstract
Furosemide was effective in improving Cdyn in a group of pre-term infants suffering from respiratory distress syndrome (RDS) during the first week of life, but had no effect on another group with bronchopulmonary dysplasia (BPD) studied at a later age. Eight infants (BW 1530+/−500g, GA 32+/−2wks) with RDS were studies at 2+/−1 day of age, and eight (BW 840+/−390g, GA 29+/−3 wks) with BPD at 35+/−25 days. Cdyn and PO2 were measured immediately prior to the intravenous infusion of furosemide 1mg/kg and again 20 minutes post infusion. Eight infants (BW 1570+/−520g, GA 32+/−2wks) served as RDS controls, evaluated on day 3+/−2 without furosemide. The results are noted below:
The rise in Cdyn in the RDS group was significantly greater than the responses in both control and BPD infants. In this group of infants furosemide was effective in improving compliance in infants with respiratory failure in the early course of RDS but was ineffective in the later complication of BPD.
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Graff, M., Novo, R., Smith, C. et al. 1769 THE EFFECT OF FUROSEMIDE ON COMPLIANCE (CDYN) IN ACUTE AND CHRONIC PULMONARY FAILURE. Pediatr Res 19, 405 (1985). https://doi.org/10.1203/00006450-198504000-01787
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DOI: https://doi.org/10.1203/00006450-198504000-01787
