Abstract
BPD may be due to lung connective tissue damage caused by oxidants and proteolytic enzymes in prematures with RDS who are treated with ventilators and oxygen. Antiproteases, such as AAT, may protect the lungs against this destruction. To study its potential role we measured plasma trypsin inhibitory capacity (TIC) (Erlanger method) in 27 prematures who required ventilator therapy for treatment of RDS. Day 1 TIC values were significant ly lower (p<0.0001) in the 13 patients who developed BPD when compared to the 14 who did not, other significant variables included birthweight (p<.0.005), severity of RDS (p<0.03) and gestational age (p<0.05). One way analysis of variance demonstrated day 1 TIC to be the most significant variable (p<0.00001) followed by birth weight (p<0.0175), severity of RDS (p<0.058) and gestational age (p<0.0739). A composite of these 4 variables (TIC, birth weight, severity RDS and gestational age), were 100% sensitive and 86% specific in the prediction of BPD. Decreased TIC on day 1 may be of pathogenetic and prognostic significance in the development of BPD.
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Rosenfeld, W., Concepcion, L., Zabaleta, I. et al. 1822 ALPHA 1 ANTITRYPSIN IN THE PREDICTION OF BRONCHOPULMONARY DYSPLASIA (BPD). Pediatr Res 19, 414 (1985). https://doi.org/10.1203/00006450-198504000-01840
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DOI: https://doi.org/10.1203/00006450-198504000-01840
