Abstract
Oxidant injury during ventilation therapy in prematures with RDS has been postulated as a possible cause of BPD. Antioxi-dants, such as ceruloplasmin (CER), may provide protection against the occurrence of BPD. CER serum levels have been correlated with the degree of severity of RDS and are capable of scavenging superoxide radicals in vitro. We have evaluated the potential role of serum ceruloplasmin levels in predicting the subsequent development of BPD in 30 prematures with RDS who required ventilator therapy.
CER was not significantly lower in those patients who developed BPD when compared to those who did not.
Although patients who developed BPD had lower birth weights (p<0.005), lower gestational age (p<0.03) and had more severe RDS (p<0.03), there were no significant differences in CER levels. In both groups CER levels ranged from 33–50% of pooled adult plasma. One way analysis of variance did not demonstrate that the CER levels were a significant predictor for the development of BPD.
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rosenfeld, W., Zabaleta, I., Concepcion, L. et al. 1823 CERULOPLASMIN (CER) LEVELS IN PREMATURES AT RISK FOR BRONCHOPULMONARY DYSPLASIA (BPD). Pediatr Res 19, 414 (1985). https://doi.org/10.1203/00006450-198504000-01841
Issue date:
DOI: https://doi.org/10.1203/00006450-198504000-01841
