Abstract
Stress mediated hormonal changes in adult patients undergoing CS lead to severe post-op catabolism.Neonatal response to CS has not been studied.Stress hormones and metabolic fuels were measured in 5 TN preop,preCPB,endop,6,12,24 hr postop. A significant rise in plasma adrenaline,noradrenaline,cortisol, 11-deoxycortisol and corticosterone occurred during CS and postop.Plasma aldosterone and insulin levels did not change.Blood levels of glucose,lactate and pyruvate increased markedly whereas ketone body levels were lowered during and after CS. Marked endocrine-metabolic alterations were associated with poor clinical condition.Prevention of a catabolic stress reaction by anaesthetic/hormonal manipulation in vulnerable TN undergoing CS and CPB may improve postop outcome.
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Anand, K., Yacoub, M., Brown, M. et al. 148 ENDOCRINE AND METABOLIC REGULATION IN TERM NEONATES (TN) UNDERGOING CARDIAC SURGERY (CS)WITH CARDIOPULIMONARY BYPASS (CPB). Pediatr Res 19, 628 (1985). https://doi.org/10.1203/00006450-198506000-00168
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DOI: https://doi.org/10.1203/00006450-198506000-00168
