Abstract
First pass intravenous DSA was performed on 8 Rhesus monkeys: 5-normal (N), 1-aortic stenosis (AS), 1-ventricular septal defect (VSD) and 1-mitral regurgitation (MR). Their weights ranged from 2.8 to 7.5 kgs. Cineangiograms recorded at 30 fps using a 256 × 256 matrix were analyzed for left to right shunt (Qp/Qs) using the gamma variant method and beat-to-beat left ventricular ejection fraction (EF) using densitometric analysis of background corrected end diastolic and end systolic images. The results are as follows:
For the entire group, the 3 EF measurements varied from one another by an average of 2%.
Thus, quantitative intravenous DSA is possible in the very small subject with rapid heart rates. The monkey model may be useful for further development of methods in quantitative cardiac DSA.
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Janos, G., Seibert, J., Bogren, H. et al. 109 QUANTITATIVE INTRAVENOUS DIGITAL SUBTRACTION ANGIOGRAPHY (DSA)—A MONKEY MODEL. Pediatr Res 19, 129 (1985). https://doi.org/10.1203/00006450-198504000-00139
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DOI: https://doi.org/10.1203/00006450-198504000-00139
