Abstract
When fed ethanol (Et) from hatch turkeys develop altered Ca++ flux of the isolated cardiac sarcoplasmic reticulum (SR) and depressed LV shortening fraction (SF). This study was done to investigate the effect in turkeys of a modest intake of Et (2½%) on SR Ca++ flux and SF when given for the 1st 28 d of life compared to control (C) fed water. Similar studies were also done at 56 d comparing results of birds fed 2½% Et for 56 d, for the 1st 28 d only, and for the 2nd 28 d and 56 d C.
Ingestion of Et for the 1st 28 d of life results in altered SR Ca++ flux and decreased SF which is not enhanced by Et for 56 d. Persistence of altered SR Ca++ flux is observed at 56 d despite abstinence from Et for 28 d. Et(2½%) intake after 28 d of life does not affect SF or SR Ca++ flux.
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Noren, G., Staley, N. & Einzig, S. 124 INCREASED SENSITIVITY OF THE IMMATURE MYOCARDIUM TO ETHANOL. Pediatr Res 19, 131 (1985). https://doi.org/10.1203/00006450-198504000-00154
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DOI: https://doi.org/10.1203/00006450-198504000-00154
