134 LEFT VENTRICULAR SYSTOLIC AND DIASTOLIC FUNCTION AFTER TOTAL CORRECTION OF TETRALOGY OF FALLOT

Abstract

Left ventricular (LV) systolic and diastolic function was assessed in 12 patients after total correction of tetralogy of Fallot (TOF) and compared with 8 normal patients (N). The mean age of TOF was 10.1 years (range 5-17.8 years) at catheterization and 3.5 years (range 0.3-8 years) at surgery. Only one had a shunt prior to surgery. At catheterization the standard indexed left ventricular parameters - end diastolic volume (EDV_I), end systolic volume (ESV_I), ejection fraction (EF), stroke volume (SV_I), end-diastolic pressure (EDP), peak systolic pressure (PSP), mass (M_I) and peak systolic pressure/end systolic volume ratio (PSP/ESV_I) were obtained. L.V. diastolic operant chamber stiffness (b) & myocardial stiffness (K_E) were calculated from simultaneous diastolic pressures and volumes using monoexponential formulae. The two groups were compared by unpaired “T” tests. There was no difference in EDP, SV_I, PSP, and M_I.

Thus, TOF had higher EDV_I, ESV_I, lower EF, PSP/ESV ratios than N. Chamber stiffness was normal but myocardial stiffness (K_E) was significantly higher in TOF. A number of TOF were normal, but further analysis showed no correlation between these parameters and age at surgery.

Thus, as a group, TOF have residual systolic and diastolic abnormalities of LV function after total correction.

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