Abstract
Intravenous allopurinol loadings (17.1 μmol/kg body mass) have been performed in 12 healthy subjects and 22 patients with different liver diseases. Plasma and urine concentrations of allopurinol and oxypurinol were monitored during 180min. The concentration curves were analysed with the aid of a computer-based 3-compartment biodynamic model and the estimated model parameters compared to a "liver function score".
This test was primarily set up in order to achieve a liver function test more sensitive than other tests at hand. The best diskriminating parameter in the model was the fractional rate constant for transport of allopurinol from the plasma to the liver (k31). Good correlation was obtained between this parameter and the liver function score (r=-0.85, n=34). In a group of healthy subjects, a group of patients with slightly to moderately reduced overall liver function, and in a group with severely reduced overall liver function, k31 (min−1) was estimated to 0.141 ± 0.039 (x̄ ± SD, n=12), 0.072 ± 0.023 (n=14) and 0.025 ± 0.015 (n=8), respectively.
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Van Waeg, G., Burtnan, P., Groth, T. et al. KINETICS OF ALLOPURINOL TURNOVER AFTER I.V. INJECTION IN MAN AND ITS USE AS A MEANS TO ASSESS LIVER FUNCTION: 222. Pediatr Res 19, 780 (1985). https://doi.org/10.1203/00006450-198507000-00242
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DOI: https://doi.org/10.1203/00006450-198507000-00242
