Abstract
Previously we showed a decrease in metabolic rate in infants receiving Total Parenteral Nutrition (TPN) containing glucose + lipids vs glucose only. In the present study we measured substrate utilisation by Indirect Calorimetry (IDC) over 5 hr and from the excretion of 13CO2 during a primed constant infusion of U-13C-glucose. Glucose oxidation (GO) was measured from the 13CO2 enrichtment in breath at plateau and fat oxidation (FO) as the difference of non-protein metabolic rate and glucose oxidation. We compared metabolic rate (MR) and substrate utilisation in two groups of AGA infants on an isocaloric intake. Group I received glucose/aminoacids only, Group II received a lipid emulsion as well, fat intake 2.0±0.1 g/kg/d. Birthweight (2.5±0.2 vs 2.7±0.2 kg), gest. age (35.9±1.0 vs 36.9±1.0 wk), study weight (2.5±0.2 vs 2.7±0.2 kg) and postnatal age (18.7±2.4 vs 13.2±2.0 d) was not different between groups.
Conclusions: 1. The replacement of glucose by fat results in a lower metabolic rate, presumably as a result of a decreased conversion of glucose into fat. 2. Fat intake is almost equal to fat oxidation at an intake of 2 g/kg/d. 3. AGA newborn infants oxidize fat efficiently. 4. TPN with lipids has advantages above glucose/amino acids only.
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Sauer, P., Van Aerde, J., Smith, J. et al. THE EFFECT OF ADDING LIPIDS TO THE INTRAVENOUS FEEDING OF NEWBORN INFANTS. Pediatr Res 19, 1078 (1985). https://doi.org/10.1203/00006450-198510000-00059
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DOI: https://doi.org/10.1203/00006450-198510000-00059
