Abstract
Children heterozygous for familial hypercholesterolemia(FH)usually are placed on a fatmodified diet(FMD) in an attempt to lower the elevated serum levels of atherogenic IDL. Results on a cholesterol lowering effect of soy bean protein diet (SBPD) in adults are controversial and studies on SBPD in children with FH have not been performed so far.
We determined serum cholesterol (C), triglycerides(TG), lipoprotein-C and apolipoproteins (Apo)A-I,A-IIand B in 10 children heterozygous for FH(age 2-16yrs.) before and during 2 weeks of dietin a controlled clinical situation. 8 children received FMD (total fat<35J%,P/S ratio> 1,5,C<300mg/day) and 6 received SBPD (FMD+partial replacement of dietary protein by 20g of purified soy bean protein/day). 4 of the 10 children completed a crossover study receiving both diets for 2 weeks in hospital followed by 2 months of outpatient treatment. Results (mg/dl, x±sd):
These data show that diet alone is insufficient for normalizing IDL-C or ApoB in most children with FH.No marked difference betweenboth diets concerning the effect on LDL-C or ApoB was apparent. Preliminary results of the crossover study suggest a favorable effect of SBPD on LDL-C.
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Widhalm, K., Strobl, W., Zwiauer, K. et al. EFFECT OF SOY BEAN PPOTEIN ON LIPOPROTEINS AND APOLIPO-PROTEINS IN CHILDREN WITH FAMILIAL HYPERCHOLESTEROLEMIA. Pediatr Res 19, 1086 (1985). https://doi.org/10.1203/00006450-198510000-00109
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DOI: https://doi.org/10.1203/00006450-198510000-00109
