Abstract
Since the introduction of sodium cromoglycate, attempts have been made to develop a drug with similar activity when taken orally. M&B 22,948 is an orally absorbed mast cell stabiliser which has previously been shown to block exercise induced asthma in adults. We conducted a trial in which 15 children with asthma each undertook three exercise challenges. They were pretreated with either M&B 22,948 or placebo, given double-blind, in randomly allocated order, prior to the second and third challenges. Our results failed to show a protective effect of M&B 22,948 against exercise induced asthma but the possible reasons for the discrepancy with the previous trial will be discussed.
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Reiser, J., Yeang, Y. & Warner, J. THE EFFECT OF M&B 22,948 (AN ORALLY ABSORBED MAST CELL STABILISER) ON EXERCISE INDUCED ASTHMA IN CHILDREN. Pediatr Res 19, 1098 (1985). https://doi.org/10.1203/00006450-198510000-00177
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DOI: https://doi.org/10.1203/00006450-198510000-00177
