Abstract
Chlamydia /C./ trachomatis harboured in the maternal genital tract can be transmitted from mother to infant during parturition. Infection of the neonate may lead to colnjunctivitis in the first life days or/end after a few weeks to atypical pneumonia with or without conjunctivitis, Serology is a most reliable approach to verification of C. trachomatis as the causative agent in lower respiratory infection in infants between 1-6 months of age.
In 1983-85 1 to 3 serum samples of 76 young infants with atypical pneumonia were tested for A-K serotypes of C.trachomatis antibodies with indirect microimmunofluorescent method. Detection of antibodies was also carried out in serum samples of mothers whose children had a positive serological result. Serology provided evidence for chlamydial pneumonia in 9 patients. Elevated Chlamydia-specific antibody titres/128-2048/were registered. High serum concentrations of antibodies in titres 512-8192 were found in the sera of mothers, proving genital C.trachomatis infection. Positive chlamydial serology in atypical pneumonia of infants defines antibacterial therapy: erythromycin is the antibiotic of choice in infantile chlamydial infection.
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Marton, A., László, V., Szirmai, Z. et al. SEROLOGICAL STUDIES IN CHLAMYDIA TRACHOMATIS ASSOCIATED PNEUMONIA IN INFANTS. Pediatr Res 19, 1110 (1985). https://doi.org/10.1203/00006450-198510000-00242
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DOI: https://doi.org/10.1203/00006450-198510000-00242
