Abstract
The hemodynamics of combination therapy: indomethacin(IND) and dobutamine(DOB) or dopamine(DOP) in endotoxin(ETX) shock were studied in newborn mongrel puppies. 51 puppies (2–10days, 270–800gm) were divided into 4 groups: Group 1(n=14) received 1.5mg/kg E.coli. Group 2(n=ll) received ETX+IND(1.5mg/kg). Group 3(n=ll) received IND+DOB(5mcg/kg/min). Group 4(n=15) received ETX+IND+DOP(5mcg/kg/min). The heart rate, mean arterial pressure (MAP), cardiac output(CO), systemic vascular resistance and minute work were obtained before and serially to 120 min. IHD was injected 5 min. after ETX. DOB and DOP were infused from 5 min. to 120 min.
Results: Treatment with IND maintained MAP and diminished the fall in CO. After IND+DOB, both MAP and CO decreased, but the response to ETX was attenuated. IND+DOB, however maintained both MAP and CO.
These data suggest that the hemodynamic effects of ETX shock may be modified or reversed optimally by a combination of IND+DOP. This combination may be useful in the clinical treatment of septic shock in the newborn.
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Goto, M., Griffin, A. & Cutilletta, A. 183 TREATMENT OF ENDOTOXIN SHOCK IN NEWBORN ANIMALS WITH INDOMETHACIN, DOBUTAMINE AND DOPAMINE. Pediatr Res 19, 141 (1985). https://doi.org/10.1203/00006450-198504000-00213
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DOI: https://doi.org/10.1203/00006450-198504000-00213
