Abstract
To determine the effect of decreasing systemic oxygen delivery (SOD) on oxygen consumption (Vo2) in the growing neonatal subject, we conducted 15 studies in 5 three week old lambs. SOD was lowered by progressive pericardial tamponade. SOD was measured as the product of cardiac output (CO) and arterial oxygen content. CO was measured by thermodilution. Pulmonary mixed venous and arterial blood were used to measure Po2, O2 saturation and hgb. Measurements were made every twenty minutes in unanesthetized, spontaneously breathing lambs in which decremental decreases in CO were produced. The change in Vo2 with decreasing SOD was analyzed by grouping data in decreasing ranges of SOD. The chart presents the mean± SD in each range:
The increase in extraction and the decrease in Vo2 were both significant by ANOVA (p <.001). The data suggest that Vo2 falls in the growing lamb despite an initial, but submaximal increase in extraction. The growing animal may be particularly compromised by decreases in SOD.
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Vallone, A., Morriss, F. 221 EFFECT OF DECREASING LEVELS OF OXYGEN DELIVERY ON TOTAL BODY OXYGEN CONSUMPTION IN GROWING LAMBS. Pediatr Res 19, 147 (1985). https://doi.org/10.1203/00006450-198504000-00251
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DOI: https://doi.org/10.1203/00006450-198504000-00251
