Abstract
Dopamine (Dp) is widely used in the hemodynamic support of infants. Previous studies have shown contradictory effects of Dp on systemic and pulmonary vasculature. We hypothesized that oxygen status could affect the hemodynamic response to Dp. Seven healthy, <10 day old acutely instrumented lambs were studied. Catheters were placed in the pulmonary artery (Ppa), left atrial, inferior vena cava and descending aorta (Pas); and electromagnetic flow probe was placed around the main pulmonary artery (Qpa). Doses of Dp (5, 10, 15 and 50 μ/Kg/min.) and PaO2 status were randomized. Each dose of Dp was given for 5 min.
The difference in response to each dose may be due to activation of different catecholamine receptors. If neonates with normal hearts respond in similar fashion to these lambs, Dp may not be an appropriate pressor in normoxia except at very high doses. We observed arrythmias in 1/7 animals at 50 μ/Kg/min. Also, Dp should be used with caution in hypoxic neonates because of the tendency for Ppa to increase while Ppa remains unchanged. This could precipitate or worsen right-to-left ductus art. shunting.
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Godoy, G., Lvrene, R., Cassadv, G. et al. 366 HEMODYNAMIC EFFECTS OF DOPAMINE. Pediatr Res 19, 171 (1985). https://doi.org/10.1203/00006450-198504000-00396
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DOI: https://doi.org/10.1203/00006450-198504000-00396
