Abstract
As part of a study of factors affecting G pharmacokinetios in neonates, we recommended a modified dosing interval for preterm babies: q12° if ≥38 wks gestational age (GA), q18° if 30-37 wks GA, and q24 if <30 wks GA. After 3 doses, 3 G levels were drawn and pharmacokinetlcs analyzed. To evaluate the effect of the modified dosing schedule, we reviewed a 6 month period prior to the study (72 courses of therapy in 67 patients ≤37 wks) and compared peak and trough levels with calculated peak and trough levels from a 6 month period during the study (71 courses in 65 patients ≤37 wks). Control (C) infants had received G at 8°(2), 12°(56), 18° (13) and 24°(1) intervals. Study (S) infants received G at 8°(2), 12°(16), 18°(3*0 and 24°(19) intervals. The table shows values that fell outside the accepted therapeutic range.
Of the 8 study infants with troughs >2μg/ml, only 3 had actually been dosed at the recommended interval. We conclude that this simple modification of the G dosing interval in the preterm neonate significantly decreases the number of elevated troughs without compromising the attainment of therapeutic peak levels.
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Watterberg, K., Kelly, H. & Johnson, J. 423 MODIFIED GENTAMICIN (G) DOSING SCHEDULE FOR PRETERM NEONATES. Pediatr Res 19, 181 (1985). https://doi.org/10.1203/00006450-198504000-00453
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DOI: https://doi.org/10.1203/00006450-198504000-00453
