Abstract
Studies of absorptive capabilities of prematures have been limited by incomplete stool collections where loss of even small portions of the usual 5-10 gm stool output/day introduces a large percent error. We evaluated the usefulness of a continuous oral internal marker (PEG) to correct for stool losses and variations in fecal flow in 4 prematures(Av. wt 1.7 kg). Total formula and PEG intake were monitored and 24-hour stool collections done using plastic-lined diapers. Formula and stools were analyzed for PEG and carbohydrate(CHO) content utilizing methods that yielded 95% recovery of PEG and CHO.
Conclusions: 1) PEG output/gm stool became constantf (Av. variability 15%) by 3-5 days(vs 2 wks in adults). 2) There was wide variability in daily stool wt (0-32.6 gm) and %PEG recov(0-217%) but these correlated strongly(r=. 92, p<.001). %PEG recov did not vary with the dose adm. 3) Therefore stool wt and CHO excretion per day could be corrected by %PEG recov, decreasing their coefficient of variation(V).
Our results confirm previous concerns about the adequacy of stool collections and suggest an internal marker may be feasible for correction in premature balance studies.
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Ameen, V., Powell, G. 609 INTERNAL STANDARD (PEG) FOR BALANCE STUDIES IN PRE-MATURES. Pediatr Res 19, 212 (1985). https://doi.org/10.1203/00006450-198504000-00639
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DOI: https://doi.org/10.1203/00006450-198504000-00639
