Abstract
Indomethacin (ID) which is used with increasing frequency to stop preterm labor, impairs renal function in the preterm infant, when given postnatally. We studied serum ID levels and renal function in premature infants born despite ID therapy during pregnancy. Ten preterm infants, mean gestational age 29.5 wk (range 27.5 to 31 wk), were studied (group I). We used the continuous inuline infusion technique for measuring glomerular filtration rate (GFR). GFR, serum creatlnine (Screat), osmolal clearance (Cosm), free H^O clearance (CH2O) and fractional sodium excretion (FeNa) were measured on day 2, 3 and 4. Six preterm infants whose mother did not receive ID served as controls (group II). Serum ID levels measured directly after birth varied from 1.9 ng/ml to 0.1 ng/ml in group I. For renal function parameters (±SD) see table.
Urine production returned to normal as did Screat within the first weeks of life. Conclusions: 1) ID given during pregnancy impairs renal function after birth. 2) Fluid intake should be reduced in these infants 3) ID levels found in our patients were comparable to levels found by ID administration for closure of the Ductus Botalli. 4) The effect on renal function Is temporary.
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Sauer, P., Grose, W., Oranje, W. et al. 1 INDOMETHACIN AS AN INHIBITOR OF PREMATURE LABOUR: THE EFFECT ON RENAL FUNCTION POSTNATALLY. Pediatr Res 20, 1034 (1986). https://doi.org/10.1203/00006450-198610000-00055
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DOI: https://doi.org/10.1203/00006450-198610000-00055
