Abstract
Atrial natriuretic peptide (ANP) is the most potent endogenous natriuretic/diuretic substance described to date. Recent iinmunohistochemical studies and tests based on radioimmunoassays indicate that AHP is present in the central nervous system. In our studies, we investigated the effect of ANP in a superfused rat pituitary cell system. When ANP was administered at increasing concentrations (10−8 M to 10−6 M), it caused a significant, dose related stimulation of the release of luteinizing hormone (LH) and follicle stimulating hormone (FSH). The lowest effective dose of ANP in our system was 3×108 M. When ANP and luteinizing hormone-releasing hormone (LH-RH) were administered together, the response was prolonged and had the characteristics of ANP stimulated LH and FSH release. In contrast with some previous reports, ANP in high concentration (10−6 M) consistently induced a small but significant stimulation of the release of corticotropin. ANP did not influence the basal release of prolactin, growth hormone and thyrotropin.
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Ertl, T., Horváth, J. & Schally, A. 45 EFFECT OF ATRIAL NATRIURETIC PEPTIDE ON THE HORMONE RELEASE IN SUPERFUSED RAT PITUITARY CELLS. Pediatr Res 20, 1041 (1986). https://doi.org/10.1203/00006450-198610000-00099
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DOI: https://doi.org/10.1203/00006450-198610000-00099
