Abstract
Exchange transfusion and/or dialysis are the usual treatment of hyperammonemic coma with its high mortality rate. In this Table we present the effect of forced diuresus (FD) and Lasix, 1-3 mg/kg i.v., on 4 infants (age 2-90 days) with hyperammonemic coma due to either hypercitrullinemia (1,2) or organic acidemia (3,4).
After FD and Lasix ammonia decreased significantly by 35% in 1.75 hours and 65 to 92% at 24 hours and remained within normal range with diet and appropriate drug therapy.
All patients recovered from coma after therapy. We conclude that the treatment of hyperammonic coma in infants with FD and Lasix is an effective, fast and non-invasive method.
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Abu-Osba, Y., Hamdan, J. & Mathew, R. 169 TREATMENT OF HYPERAMMONEMIC COMA BY LASIX AND FORCED DIURESIS. Pediatr Res 20, 1062 (1986). https://doi.org/10.1203/00006450-198610000-00224
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DOI: https://doi.org/10.1203/00006450-198610000-00224
