Abstract
GH secretion was evaluated in 54 short patients with mean growth retardation of 3.3 ± 0.96 SD ( 32 M and 22 F aged 5 to 19 years), comparing their peak response to GRF 1-44 Sanofi 2 μg/kg IV (GRF P) and to 2 conventional pharmacologic stimuli (arginine, insulin, glucagon, ornithine) (PS P) with the peak value of their sleep secretion (SS P). GRF P was more significantly correlated with PS P(r = 0.53, p< 0.001) than with SS P (r = 0.33, p<0.02).
The patients have been classified into 5 groups according as usually to the sleep and pharmacologic GH levels: group I = 26 endocrinologically normal with both PS and SS peaks > 10 ng/ml; group II = 5 completely GH deficient with both PS and SS peaks <C 6 ng/ml; group III = 8 partially deficient with both PS and SS P 6 to 10 ng/ml; group IV = 9 with normal SS P and low PS P; group V = 6 with low SS P and normal PS P.
GRF P (x̄ ± SEM) was 39 ± 5.B ng/ml in group I, 12 ± 3.4 in group II, 24 ± 3.7 in group III, 12 ± 5.0 in group IV and 21 ± 5.3 ng/ml in group V. It was significantly higher in group I than in ail others ( I vs II and vs IV p < 0.001, I vs III and vs V p < 0.05). However there was a large overlap of the GRF P between the 5 groups. It is concluded that the GRF test contributes to the evaluation of GH secretion but probably does not improve the definition of atypical deficiencies.
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Garnier, P., Evain-Brion, D., Liapi, C. et al. EVALUATION OF GROWTH HORMONE (GH) SECRETION COMPARING THE RESPONSE TO 1-44 GROWTH HORMONE RELEASING FACTOR (1-44 GRF) WITH THE SLEEP SECRETION AND THE RESPONSES TO PHARMACOLOGIC STIMULI. Pediatr Res 20, 1189 (1986). https://doi.org/10.1203/00006450-198611000-00091
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DOI: https://doi.org/10.1203/00006450-198611000-00091
