Abstract
Serum levels of IGF-I, IGF-II and the low molecular form of somatomedin binding protein (SMBP) were determined in pregnant women and their infants. Longitudinal studies during pregnancy were performed in healthy women, women with GH deficiency (n=3) and women with diabetes or gestational diabetes (n=44). IGF-I, IGF-II and SMBP were determined by radioimmunoassays using polyclonal antibodies.
The serum levels of IGF-I and SMBP, but not IGF-II, increased during pregnancy in both healthy women and women with diabetes. In GH deficient women the levels rose to normal pregnant levels. The birth weight percentile of the infants increased with the maternal IGF-I levels and decreased with the maternal SMBP levels. The ratio between maternal IGF-I and SMBP levels improved the correlation to the birth weight percentile. No correlation was found between the birth weight and the isolated values of IGF-I, IGF-II, SMBP and C-peptide in cord blood. The IGF-II levels in cord blood from infants of diabetic women were 50% higher than those of nondiabetic women.
The correlation between maternal levels of the birth weight of the infants indicates that maternal IGF-I levels may play a role in the transfer of nutrients to the fetus. The elevated IGF-II levels in cord blood of infants of diabetic women suggest that IGF-II could participate in the glucose homeostasis of the fetus.
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Hall, K., Hansson, U., Lundin, G. et al. SERUM LEVELS OF SOMATOMEDINS AND SOMATOMEDIN BINDING PROTEIN IN PREGNANT WOMEN AND THEIR INFANTS. Pediatr Res 20, 1192 (1986). https://doi.org/10.1203/00006450-198611000-00112
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DOI: https://doi.org/10.1203/00006450-198611000-00112
