Abstract
A few studies have suggested that s-thyroglobulin (Tg) in cord blood is higher in premature (PT) than in fullterm (FT) babies. S-Tg was determined by RIA in 33 routinely sampled blood from 33 infants. S-Tg ranged from 2.5-148 ug/l, median 33 ug/l, signficantly higher than in adults (p < 0.001). Subsequently, detailed informations on s-Tg, T4, T3, TSH, and thyroid hormone-binding proteins TBG, TBPA, and albumin were conducted in 14 FT, in 6 small-for-date (SGA) infants born at term (chron.age l-303 days, weight 2400-9000 g) and in 12 PT babies (gest.age 33-36 weeks, chron.age 50-970 days, weight 2930-11800 g).
Results: 1) Wide range values of s-Tg were seen, 21-108 ug/l, median 42 ug/l, in FT, SGA and PT-infants, with no significant differences between the groups, but higher levels than in adults. 2) S-Tg did not change significantly with chronologocal age or body-weight (R -0.41, p> 0.1) in the material as a whole, but in FT-infants s-Tg was correlated to s-T4 (R 0.48, p=0.05). Individual data showed a decrease of s-Tg with age and increase with s-T3. 3) No correlation was found between s-Tg and s-TSH or thyroid hormone-binding proteins (p> 0.1).
Conclusion: S-Tg is increased in FT, SGA and PT-infants compared to adults, but do not correlate to maturity. These findings have to be considered at the neonatal thyroid screening programmes.
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Jacobsen, B., Feldt-Rasmussen, U. SERUM THYROGLOBULIN CONCENTRATIONS IN INFANTS OF VARIOUS MATURITY. Pediatr Res 20, 1193 (1986). https://doi.org/10.1203/00006450-198611000-00118
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DOI: https://doi.org/10.1203/00006450-198611000-00118
