Abstract
This study was designed to assess the relationship between diabetes control (monitored by yearly or more frequent HbA1 determinations) and the ocular and renal complications of type I diabetes. 149 patients (aged ≥ 14 years) with type I diabetes ≥ 5 years had microalbumin excretion rates (AER) determined in resting, peak exercise and overnight urine samples. They also had complete eye exams (including fluorescein photography and fluorophotometry). HbA1 levels were available (normal=6.3 to 8.2) for the previous 3 to 8 years for all subjects.
99 subjects had a normal AER on all 3 urine samples. An elevated AER (> 30 μg/min) was found with exercise in 26 and 24 had elevated levels in all 3 samples. The mean HbA1 for those with all normal AER was 11.5± 1.3 (± 1 S.D.) compared to 12.7 ± 1.5 for those with any elevated AER (t-test: p<0.0001).
60 cases had no eye changes and had a mean longitudinal HbA1 of 11.4 ± 1.6 compared to 89 subjects with ocular changes who had a mean HbA1 of 12.2 ± 1.3 (t-test: p<0.0008).
Chi-square analysis showed a significant relationship (p<0.03) between the presence of elevated AER and of ocular changes.
This study shows a relationship between longitudinal glucose control during childhood and the ocular and renal alterations of type 1 diabetes.
Supported in part by NIH Clinical Research Center grant RR-69.
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Chase, H., Jackson, W., Hoops, S. et al. DIABETES AND OCULAR AND RENAL COMPLICATIONS. Pediatr Res 21 (Suppl 4), 340 (1987). https://doi.org/10.1203/00006450-198704010-01037
Issue date:
DOI: https://doi.org/10.1203/00006450-198704010-01037
