Abstract
In order to evaluate the role of CBF in the pathogenesis of periventricular haemorrhage and leukomalacia, we measured CBF with the non-invasive Xenon-133 clearance method. Intravenous application of Xenon and registration of its clearance with Cadmium Telluride detectors was performed inside the incubator. Twenty premature babies (mean birth weight, ±SD, 1050 ±180g, gestational age 29 ±2 weeks) had one to three CBF measurements at a postnatal age of < 26h (CBF1), at 26-120h (CBF2), and at 120-206h (CBF3). The results show a mean CBF1 (ml/100g.min,±SD) of 12.4 (±1.5), CBF2 21.4 (±4.1), and CBF3 16.6 (±3.8) in babies with normal ultrasound (US). A similar time course, with a. peak CBF2, was found in those with abnormal US. Interestingly, all these values were highest in those with intraparenchymal (±intraventricular) US anomalies: CBF1 19.1 (±6.9), CBF2 23.5 (±3.5), CBF3 21.5 (±7.3). This flow elevation might represent hyperaemia similar to the luxury-perfusion syndrome described by Lassen N.A. (Lancet ii: 1113-1115, 1966) in adults, and could be due to a loss of autoregulation.
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Lipp, A., Jäggi, J., Mieth, D. et al. FACTORS INFLUENCING CEREBRAL BLOOD FLOW (CBF) IN PREMATURE BABIES DURING THE FIRST WEEK AFTER BIRTH. Pediatr Res 22, 230 (1987). https://doi.org/10.1203/00006450-198708000-00100
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DOI: https://doi.org/10.1203/00006450-198708000-00100
