Abstract
The inbred S/JR rat is characterized by a genetic predisposition to NaCl-induced hypertension (III). Although mature S/JR but not R/JR rats develop HT when fed a high NaCl-contalning diet, this effect has not been examined in the pre-weaning state. S/JR and R/JR dams were maintained on 0.15% (w/w) or 8% (w/w) NaCl diets throughout gestation and lactation. Measurements of abdominal aortic blood pressure (MAP, mmHg) were obtained in anesthetized (Ketamine 25 mg/kg and Xylazine 3 mg/kg i.p.) offspring at 5, 15 and 25 days of age. Values = mean ± SEM; n = 8-14 rats/group.
*p<.05 vs. age-matched S/JR on same diet; +p<.05 vs. strain- and age-matched rats on 8% diet; S/JR exposed to 8.0% died (NA). A hypertensinogenic effect of 8% NaCl was seen in R/JR rats at 5 and 15 days. BP in S/JR rats was consistently higher. Ontogeny of BP may be determined by pre- and postnatal dietary NaCl.
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Devarajan, P., Persan, L., Kaskel, F. et al. ONTOCENY OF BLOOD PRESSURE (BP) IN THE INBRED DAHL HYPERTENSION–SENSITIVE (S/JR) AND -RESISTANT (R/JR) RAT. Pediatr Res 21 (Suppl 4), 189 (1987). https://doi.org/10.1203/00006450-198704010-00138
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DOI: https://doi.org/10.1203/00006450-198704010-00138
