Abstract
We studied the potential desorption of aspirin (ASA) from activated charcoal (AC) in 8 volunteers in a cross-over study. Separated by 10 days, subjects received either 1 gm of ASA in solution or a slurry of 1 gm of ASA with 10 gm of AC. Complete binding of ASA to AC was assured by assay of the effluent. These solutions were incubated for 15 minutes before ingestion. Blood was obtained at 0, .5, 1, 2, 4, 6, 8, 10, 12, 24 and 30 hrs post ingestion and plasma salicylate concentrations were determined by HPLC.
Our results further demonstrate that (1) the t1/2 between 4 and 12 hrs was not different in the ASA (5.5 hrs) and ASA/AC (4.6 hrs) groups (p>0.05); (2) the t1/2 was different in the ASA (5.5 hrs) and ASA/AC (21.8 hrs) groups between 12 and 30 hrs and (3) ASA concentrations were greater at 24 and 30 hrs in the ASA/AC vs ASA group (p<0.05). We conclude that in these doses, ASA binding to AC is reversible and may act as a delayed release preparation.
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Lacouture, P., Fish, S., Filitpone, G. et al. DESORPTION OF ASPIRIN FROM ACTIVATED CHARODAL. Pediatr Res 21 (Suppl 4), 237 (1987). https://doi.org/10.1203/00006450-198704010-00418
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DOI: https://doi.org/10.1203/00006450-198704010-00418
