Abstract
Although the rhesus monkey is an excellent model of human growth hormone physiology, no developmental survey of serum concentrations of the growth hormone dependent somatomedin, insulin-like growth factor 1 (IGF-1), is available. Thus, we studied serum values of IGF-1 collected between birth (NB) and 17 years (17yr) of age in 83 animals in a cross-sectional study and between 3 months (3M) and 4 years (4yr) of age in 6 animals in a longitudinal study. RIA incorporated antibody to IGF-1 (provided by the NHPP), synthetic IGF-1 (provided by Dr. C.H. Li) as radioligand, and pooled rhesus monkey serum as standard. All sera were extracted with acid-ethanol to eliminate the effects of binding proteins. Results from the cross-sectional study were (values in U/ml):
Pubertal animals of 2-4 years had significantly higher values than younger or older animals (p<.001). There was a correlation of bodyweight with IGF-1 values in the males (R2=.717, p<.0005). This trend was confirmed in the longitudinal study. In conclusion, the rhesus monkey, like the human being, has higher IGF-1 values during the pubertal period, and should afford a useful model of IGF-1 regulation in human development.
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Styne, D., Falloon, L. & Barry, S. INSULIN-LIKE GROWTH FACTOR 1 IN THE DEVELOPING RHESUS MONKEY. Pediatr Res 21 (Suppl 4), 255 (1987). https://doi.org/10.1203/00006450-198704010-00525
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DOI: https://doi.org/10.1203/00006450-198704010-00525
