Abstract
Studies have shown the beneficial effect of normo- and hyper insulinemia on growth rate of GHD children due to craniopharyngioma (BUCHER et al.). Furthermore others showed that insulinotropic drugs improve growth parameters in experimental and clinical situations. To test whether increased insulin secretion or decreased degradation is responsible for improvement of insulinemic status c-peptide (c-p.), insulin (IRI) and glucose responses to 1.75 g/kg b.w. glucose p.o. as well as insulin binding of erythrocytes were measured simultaneously. After informed consent 1Ø (GHD) children were tested during GH thera py (phase 1) and after more than 6 weeks (phase 2) withdrawal. Glycemic response was normal in both situations, max.IRI and c-p . were reduced as compared to age-matched normal values in both phases. IRI levels were significantly higher in phase 1 than 2, but c-p. showed only a slight insignificant increase in the older age group. Insulin binding (7.5%+-0.8 vs.5.5 +- 0.6 S.D.) and affinity were reduced in phase 2. Comparable results of binding studies were obtained after 7 days of GH-withdrawal. Our results showed down-regulated receptors in phase 1 as evidence of permanently increased insulin levels. We conclude decreased hepatic degradation under GH.
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Mohnike, K., Hildebrandt, R., Starke, I. et al. DECREASED INSULIN DEGRADATION AFTER GROWTH HORMONE (GH) AS ONE REGULATORY FACTOR FOR IMPROVEMENT OF INSULIN IRI IN GH DEFICIENT CHILDREN. Pediatr Res 23, 123 (1988). https://doi.org/10.1203/00006450-198801000-00130
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DOI: https://doi.org/10.1203/00006450-198801000-00130
