Abstract
GH-tests in 55 children with short stature were compared: 24 hour (q2hr), sleep induced (6hr, q 30 min), Arginin(A)- (0.5 g/kg BW), Insulin(I)- (0.05 μ/kg BW) and GHRH- (1 μg/kg BW GHRH 1-44) stimulated GH-secretion and baseline SMC (U/ml). 20 patients had been diagnosed as growth hormone deficient (GHD; 10 off treatment > 1 year, 10 newly diagnosed) and 35 classified as Non GHD (NGHD) according to a normal spontaneous GH-secretion. Clinically, both groups were similar (CA, BA, growth velocity), GH-levels differed significantly (p < 0.01).
In GHD ail tests correlated significantly (p<0.001), in NGHD no correlation was detected. 28 NGHD-patients were verified as constitutional delay (CD) (normal Arg/Ins, normal GHRH and SMC). In 7 NGHD-patients formerly included among CD, additional information was gained by GHRH and SMC results. 3 had pituitary dysfunction (low Arg/Ins and GHRH, normal SMC), 3 had partial GHRH deficiency (low SMC and GHRH, normal Arg/Ins) and 1 had SMC resistance (high Arg/Ins, high SMC and high GHRH).
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Grüters, A., Schnabel, K., Schnabel, D. et al. GHRH-TEST AND SOMATOMED IN C (SMC) GIVE ADDITIONAL INFORMATION IN THE DIAGNOSTIC PROCEDURE OF SHORT STATURE IN CHILDREN. Pediatr Res 23, 123 (1988). https://doi.org/10.1203/00006450-198801000-00134
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DOI: https://doi.org/10.1203/00006450-198801000-00134
