Abstract
ABSTRACT: The cause(s) of excessive fecal bile acid loss in cystic fibrosis (CF) has not yet been fully determined, but in vitro studies have suggested that a primary mucosal defect in ileal bile acid uptake may be of importance. To examine this mechanism in vivo, the terminal ileal uptakes of taurocholate and glycocholate were determined using a marker-perfusion technique in three CF infants and four controls. Normal and CF ileal conditions were simulated by varying the taurocholate:glycocholate concentration ratio (normal 1:1, CF 1:4) and pH (normal 7.8, CF 6.0) of the perfusate. The mean bile acid uptake under normal perfusate conditions was not significantly different in CF subjects (taurocholate 0.124 μmol/min/cm ileum ± SD 0.127, glycocholate 0.117 μmol/min/cm ileum ± 0.114), and controls (0.142 ± 0.164 and 0.115 ± 0.120 respectively). Similarly, under CF conditions, bile acid uptake values in CF subjects and controls were similar. The results are not consistent with deranged ileal bile acid reabsorption being a major cause of fecal bile acid loss in CF.
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Thompson, G., Davidson, G. In Vivo Bile Acid Uptake from Terminal Ileum in Cystic Fibrosis. Pediatr Res 23, 323–328 (1988). https://doi.org/10.1203/00006450-198803000-00018
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DOI: https://doi.org/10.1203/00006450-198803000-00018
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