Abstract
Recent evidence suggests that normal growth during male puberty depends on the combined effect of testosterone(T) and growth hormone while the role of estrogens, if any, has not been established. Correlations between growth velocity (GV) and serum totalT(Tb T), non-SHEG-b T, To E2 or non-SHEG-b E2 was made in 16 normal boys (mean ± SD chronological age, 14.1 ± 1.4, mean ± SD bone age 12.3 ± 1.64 years) in Tanner's stages II-IV of genital development. GV was evaluated in a 6-months-period but growth was followed up for at least 1 year. None of the subjects had overcome their peak height velocity as judged by 3 consecutive measurements. T and E2 non-SHEG-b fractions were calculated by a mathematical model based on the law of mass action. Mean ± SD To T and non-SHEG-b T were 222 ± 48 and 75 ± 22ng/dl respectively while To E2 and non-SHEG-b T were 222 ± 48 and 75 ± 22ng/dl respectively while To E2 and non-SHEG-b E2 were 18.1 ± 4.4 and 9.07 ± 2.88 pg/ml respectively. To T and non-SHEG-b T shoed a highly significant correlation with GV (p < 0.001) while no significant correlation was found between To E2 or non-SHEG E2 and GV. These studies suggest that serum E2 does not play a role in the pubertal growth spurt of boys.
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Belgorosky, A., Martínez, A., Escobar, M. et al. 26. LACK OF CORRELATION OF TOTAL ESTRADIOL (To E2) AND NON-SHBG-BOUND E2 (non-SHBG-b E2)WITH GROWTH VELOCITY DURING PUBERTY IN NORMAL BOYS. Pediatr Res 23, 651 (1988). https://doi.org/10.1203/00006450-198806000-00049
Issue date:
DOI: https://doi.org/10.1203/00006450-198806000-00049
