Abstract
It is noteworthy the region of amino acid sequence homology between A gliadin and the early region E1b protein of human adenovirus 12 /Ad 12/. The encounter of immune system with E1b protein produced during viral infection may be important in the pathogenesis of coeliac disease /CD/ because of immunological cross reactivity. We have investigated the prevalance of neutralising antibody to Ad 12 among children with treated CD /16 girls, 7 boys, moan age: 8, 7 years, range: 4.0 - 13.9 years/. 23 age-matched children served as controls. Serial two fold dilution of sera were incubated with the same volume of 20 TCIO50 of Ad 12 at 37°C for two hours, then the mixtures were added to the test tubes containing of HEp2 cell culture. The cytopathic effects were examined after five to six days incubation. Reciprocal neutralising antibody titres greater than 4 arbitrarily were regarded as positive. 12 of 23 treated coeliac children had neutralising antibody to determinants on the structural hexon protein of Ad 12. In contrast such antibody was present in only 5 of 23 controls /p -0.05/. No correlation was found between the neutralising antibody titres and the time elapsed from diagnosis of CD. The role of Ad 12 in the pathogenesis of CD may be possible on the basis of our results.
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Kósnai, I., Arató, A., Tóth, M. et al. ADENOVIRUS 12 INFECTION AND COLLIAC DISEASE. Pediatr Res 26, 267 (1989). https://doi.org/10.1203/00006450-198909000-00025
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DOI: https://doi.org/10.1203/00006450-198909000-00025
