Abstract
As changes of erythrocyte glutathione metabolism is a sensitive index of the in vivo oxidative processes, reduced glutathione /GSH/, oxidized glutathione/ GSSG/, stability od GSH and oxidation state of haemoglobin have been measured. Datas od 11 childre with acute celias disease/ ACS/ 11 children on gluten free diet/ GFCD / were compared to those of 11 children with nutritive iron deficiency/ NID/ and to 11 healthy children as controls. Erythrocyte GSH content of ACD group elevated significantly, the GSSG level decreased compared to normal controls GSSG and GSSG/GSH ration also differed from those of NID group, and a marked difference has been measured in glutathione stability, too. In ACD group methaemoglobin and haemicrom were measured. Anomalies of erythrocyte metabolism normalised during the diet period. The decreased GSSG/ GSH value of ACD group refers to decreased activity of selenoenzym gluathione peroxidase, a significant selenium deficiency /228±158nq/gHb/ has been proved to normal controls /465± 136ng/gHb/. Our results suggest that during gluten challenge ACD patients suffer from chronic oxidant stress which partially can be explained by the weakness of scavanger system and by selenium deficiency.
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Boda, M., Nemeth, I. & Varkoyni, A. FREE RADICALS IN COLIAC DISEASE OF CHILDHOOD. Pediatr Res 26, 269 (1989). https://doi.org/10.1203/00006450-198909000-00032
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DOI: https://doi.org/10.1203/00006450-198909000-00032
