Abstract
Studies have shown increased protein turnover in adults with active Crohn's disease. To assess protein turnover 13C-leucine was administered as a primed constant infusion before and after treatment in 16 children with active disease. Patients were randomised to receive either steroids or an elemental diet.
Protein turnover decreased in 7 patients treated with steroids. In those treated with elemental diet a similar decrease was seen in 4 well grown patients. Protein turnover increased in 5 stunted patients and was associated with improved growth velocity. Elemental diets thus appear particularly useful in stunted patients. Measurement of protein turnover may be a useful means to predict growth improvement.
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Thomas, A., Taylor, F., Miller, V. et al. PROTEIN TURNOVER IN CHILDHOOD CROHN'S DISEASE. Pediatr Res 26, 277 (1989). https://doi.org/10.1203/00006450-198909000-00080
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DOI: https://doi.org/10.1203/00006450-198909000-00080
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