Abstract
A negative feedback control exists between the content of duodenal proteases and pancreatic enzyme secretion which is mediated by CCK and secondary probably by NT.
The aim of the study was to determinate CCK and NT levels in childrens with cystic fibrosis (CF).
Methods: In 28 patients (18 M, 10 F: 1 – 16 years old) suffering from severe CF (steatorrhoea) and in 10 patients (6 M, 4 F: 2 – 16 years old) with a moderate form of CF plasma concentrations of CCK and NT were measured (RIA) before and after Kreon therapy-under basal conditions as well as 30 and 60 min. after breakfest. Control: n=9.
Results: Both, under basal conditions and after breakfest, CCK plasma levels were not changed in children with severe or moderate CF compared to controls. However, NT concentrations were significantly elevated in the basal (20 ± 4pg/ml) and postprandial state (60 ± 9 pg/ml) compared to controls (basal: 9 ± 4, postprandial 22 ± 2 pg/ml). KREON diminished both basal and postprandial levels of NT and basal CCK concentrations (before Kreon: 3.7 ± 1.3 pmol/l, after: 2.9 ± 1.9 pmol/l) in childrens with severe CF.
Conclusions: 1) CCK-mediated feedback mechanism is not operating under basal conditions in CF patients. 2) Meal-stimulated pancreatic exocrine secretion in these patients could be inhibited by higher intraduodenal loads of proteases (e.g. after Kreon). 3) Kreon therapy diminished elevated NT levels in children with CF.
Supported by Kali-chemie AG, FRG and DFG, grant Fo 73/7-8, FRG.
CCK - cholecystokinin
NT - neurotensin
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Cichy, W., Socha, J., Teisseyre, M. et al. PLASMA CONCENTRATION OF CCK AND NT IN PATIENTS WITH CYSTIC FIBROSIS BEFORE AND AFTER KREON. Pediatr Res 26, 277 (1989). https://doi.org/10.1203/00006450-198909000-00083
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DOI: https://doi.org/10.1203/00006450-198909000-00083