Abstract
Defective regulation of arachidonic acid has been hypothesized to be a basic defect in Cystic Fibrosis(CF). In order to demonstrate the role of intravenous fatty acid supplementation on Cl− transport in CF patients, we studied the influence of intralipid 20% (Kabivitrum) infusion 12 hours 10 ml/Kg, on measurement of electrical potential difference (PD) across nasal epithelia.
Ten patients, 4 males, 6 females, aged from 9 months to 24 years (m=11,7 years) with CF confirmed by clinical history and sweat test criteria, were studied juste before (IL-) and just after intralipid infusion (IL+).
PD was measured by pH-GPD PROXIMA® between nasal electrod and subcutaneous reference electrode. Results were compared to a normal healthy control group ranging from 5 months to 26 years(M=7, 5 years)
Results :
Conclusion : From this preliminary study, influence of intravenous lipid infusion on ionic transport across the epithelium of respiratory tract appear to be demonstrated for the first time in CF Patients, illustrating the experimental data concerning essential fatty acid on Cl and Na transport.
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Maherzi, A., Foucaud, P. & Navarro, J. INFLUENCE OF INTRAVENOUS FATTY ACID SUPPLEMENTATION ON NASAL TRANSEPITHELIAL POTENTIAL DIFFERENCE IN CYSTIC FIBROSIS PATIENTS. Pediatr Res 26, 279 (1989). https://doi.org/10.1203/00006450-198909000-00097
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DOI: https://doi.org/10.1203/00006450-198909000-00097
