Abstract
Increased aggregation and decreased deformation of red blood cells (RBC) may cause chromboembolic events.
Patients and methods: RBC aggregation (Myrenne Aggregometer), RBC deformabality (rheoscope), RBC surface charge (partition), plasma viscosity and several plasma proteins (radial immunodiffusion) were studied in 28 children with nephrotic syndrome (age 3-22 years) and in a control group.
Results: The children with nephrotic syndrome were divided into two groups according to the extent of proteinuria (*, P < .05):
No significant difference was observed in plasma viscosity, RBC surface charge, IgM and RBC deformability.
Conclusions: Nephrotic syndrome with marked proteinuria is associated with increased RBC aggregation due to increased concentrations of plasma macroglobulins. RBC charge does not contribute to increased RBC aggregation in these children. Increased RBC aggregation together with abnormal clotting factors may increase the risk of thromboembolic events in these children.
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Böhler, T., Schärer, K. & Linderkamp, O. Hemorheology and hemostasis in nephrotic syndrome. Pediatr Res 26, 504 (1989). https://doi.org/10.1203/00006450-198911000-00032
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DOI: https://doi.org/10.1203/00006450-198911000-00032
