Abstract
Phosphate changes in plasma and erythrocytes were studied in preterm and fullterm infants during the first two weeks of life. Group I : three preterm infants with no problems, mean gestational age (GA) 33.5±1.5(±SD) weeks and mean birth weight (B.W) 2010±250gm (±SD), group II : six preterm infants with problems (3 respiratory distress syndrom, 2 septicaemia, 1 necrotizing enterocolitis) mean GA 34±1.7 weeks, mean B.W. 2260±490 gm; group III : four full term infants with problems (2 with birth asphyxia and 2 with meconium aspiration) with mean BW 3550±490gm. Blood samples were drawn on 1st, 4th, 7th 10th and 14th day of life. All babies with problems received glucose 10% and calcium gluconate 10% (40mg/Kg/day) for the first 48 hours of life and TPN or infant formula thereafter. The mean phosphate intake in mg/Kg/day from day 4 to day 14 ranged in group I from 49±9 to 60±17 (mean±SD) in group II from 44±20 to 63±4.1 and in group III from 24±14 to 41±5. Plasma and red cell (RBC) Pi in both groups of preterms showed a steady increase during the study. There was no difference between normal and problematic preterm infants. In the full term newborns with problems Pi remained unchanged extra and intracellularly.
Values are expressed as means±SD in mg/dl.
The red cell oranic phosphate concentrations of ATP and 2, 3DPG seem to follow inorganic phosphate changes. The renal phosphate reabsorption index TmP/GFR increased progressively in all three groups of babies over the first 2 weeks of life. Sick preterm and fullterm neonates increased their ability to retain Pi during this study period. The lower Pi values in problematic fullterm infants were probably due to the lower Pi intake. This study indicates that by altering supplementation of phosphate we can alter phosphate retention in neonates.
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Cholevas, V., Andronikou, S., Challa, A. et al. EFFECT OF SUPPLEMENTAL PHOSPHORUS ON RED CELL PHOSPHATE IN PRETERM AND FULL TERM NEWBORNS (Preliminary report). Pediatr Res 26, 507 (1989). https://doi.org/10.1203/00006450-198911000-00050
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DOI: https://doi.org/10.1203/00006450-198911000-00050
