Abstract
To confirm the hypothesis that I modifies G pharmacokinetic with high risk of toxicity, we studied 48 neonates (mean gestational age (GA) 28.3 w., birth-weight 1125 g, postnatal age 4.5 d.) affected by respiratory problems and treated with following schedule ol G administration: 2.5 mg(Kg/dose every 24 h for GA <32 w. and every 18 h for GA 32-34 w. Twenty-eight neonates were treated only with G (group 1) and twenty were also treated with I (group 2). The serum G concentrations (immunofluorescence assay) were (mcg/ml):
No differences were found in G half-life <7.35±3.54 vs 8.10+.2.88 h), G volume of distribution (0.525±0.127 vs 0.445±0.263 L/Kg), serum creatinine levels (1.13±0.37 vs 1.31±0.42 mg/dl) between the two groups. Thirteen neonates (6 in group 1, 7 in group 2) had through levels >2 mcg/ml; five had peak levels >10 mcg/ml (2 in group 1, 3 in group 2). Our results confirm that I doesn't increase the risk of G toxicity in very low birth-weight infants, at least with the schedule of G administration used in this study.
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Parravicini, E., Maccabruni, M., Motta, G. et al. 29 DOES INDOMETHACIN (I) INCREASE THE RISK OF GENTAMICIN (G) TOXIITY IN VERY LOW BIRTH-WEIGHT INFANTS?. Pediatr Res 28, 282 (1990). https://doi.org/10.1203/00006450-199009000-00053
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DOI: https://doi.org/10.1203/00006450-199009000-00053
