Abstract
Recent investigations have proved that diet induced thermogenesis (DIT) is an important factor in the regulation of energy balance. The aim of the present study was to investigate DIT and its relationship with plasma insulin levels, glucose tolerance and body composition in childhood obesity. Resting energy expenditure was measured before and after the consumption of a test meal (energy (mean±SE):60.3 kJ/kg LBM, LBM=lean body mass) in 19 control (C) and 46 obese (0) children (age C:11.7+-0.5 yr, 0:12+-0.4yr; body weight C:37.4+-2.2 kg, 0:80.7-1-3.3 kg; LBM C: 29.7+-1.5 kg, 0:48.6+-2.1 kg). Oral glucose tolerance test was performed in 23 0 children (1.75 g/kg ideal body weight, max.100g glucose). In nine 0 children definitely low DIT was observed (1.2 +-0.3 kj/kg LBM/3h), while in 37 0 children (3.68+-0.3 kJ/kg LBM/3h) the DIT was similar to that of controls (3.44+-0.27 kJ/kg LBM/3h). Neither body composition, nor basal and glucose-induced plasma insulin levels showed any relationship with DIT. The quality of glucose tolerance had no influence on the DIT of 0 children either.
Conclusion: Decreased DIT can be detected in about 20 % of obese children. These children, however, cannot be distinguished from those with normal DIT either by anthropometric, or biochemical (insulin, glucose tolerance) parameters.
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Molnár, D. 35 DIET INDUCED THERMOGENESIS IN OBESE CHILDREN: EFFECT OF BODY COMPOSITION, PLASMA. INSULIN AND GLUCOSE TOLERANCE. Pediatr Res 28, 283 (1990). https://doi.org/10.1203/00006450-199009000-00059
Issue date:
DOI: https://doi.org/10.1203/00006450-199009000-00059
