Abstract
We investigated how hypoxemia before death influences HX levels in the VH post mortem, and the relationship between Hx accumulation in the VH and levels found in other extra-cellular fluids. Hx was measured with an HPLC method, in 2 groups of hypoxemic young pigs. Group 1: FiO2=.08, (PaO2:2.3-3.0 kPa) and group 2: FiO2=.11, (PaO2: 3.0-4.0 kPa). Ihe hypoxemia lasted until death; which occurred in group 1 after 175 ± 52 min. and group 2 after 283 ± 118 min. Mean ± SD are given. *:p<0.02 compared to values before hypoxemia. #:p<0.02 compared to values in other group.
In both groups, CSF Hx increased until death, while in 4 pigs plasma Hx reached a peak followed by a fall towards death. In conclusion: CSF Hx reflects hypoxemia, partly independent on degree and duration. Plasma Hx reflects the degree better than the duration of hypoxemia. Post norteia VH Hx may however, reflect the duration of hypoxemia before death better than the degree.
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Poulsen, J., Øyasæter, S., Torleiv, O. et al. 67 HYPOXANIHINE (HX) CONCENTRATION IN VTTREOUS HUMOR (VH) CEREBROSPINAL FIUID (CSF) , AND PIASMA, TOGETHER WITH URINARY: EXCRETION IN TWO HYPOXEMIC GROUPS OF YOUNG PIGS. Pediatr Res 28, 288 (1990). https://doi.org/10.1203/00006450-199009000-00091
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DOI: https://doi.org/10.1203/00006450-199009000-00091
