Abstract
We studied the possibility to improve lung distensibility by SI during the first hours of age. Preterm newborn lambs (123-133 days of gestational age, n=70) were used. Initially all lambs were mechanically ventilated with 100% O2, peak inspiratory pressure (PIP) was adjusted for paCO2. For SI the ventilator was disconnected and the lungs were inflated during five seconds at a PIP of 25 or 35 cmH2O with a mixture of 5% CO2 and 95% O2. Each inflation was followed by positive end expiratory pressure of 5 cmH2O for 5 seconds. This procedure was repeated three times. SI was applied in three groups: 1) within 15 minutes after birth, 2) within 15 minutes after birth and repeated each hour for 3 hours 3) at 4 hours of age. Two control groups (4 and 5) were formed, 4) as group 1, except that during disconnection the lungs were inflated at the same pressure as for SI, but with short inspiratory time, 5) lambs were ventilated without any manipulation. Blood gas samples were taken every 30 minutes. Compliance (Cl) was calculated from the injected volume of air per kg wet body weight needed to obtain a pressure of 20 cmH2O.
Results (mean±SEM) at 3 hours after birth:
In summary, SI as used here showed no significant changes in compliance or blood gas exchange at 3 hours of age.
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Klöpping, I., Maertzdorf, W. & Blanco, C. 155 LONG TERH EFFECTS OF SUSTAINED INFLATIONS (SI) ON LUNS FUNCTION IN PRETERM NEWBORN LAMBS. Pediatr Res 28, 303 (1990). https://doi.org/10.1203/00006450-199009000-00179
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DOI: https://doi.org/10.1203/00006450-199009000-00179
