Abstract
The role of glucocorticoids (GC) on the maturation of fetal lung is well known. HMD could be due to a quantitative and/cor qualitative anomaly of GR with a resistance to GC. In order to study this hypothesis GR were measured by the method of Scatchard in the cord blood lymphocytes of 8 premature babies. All were born before 35 weeks of gestation. 4 developed HMD (Group I); 4 didn't develope any respiratory disease (Group II). The number of GR/cell was 2700 ±1000 in group I and 9800 ± 1200 in group II (p<0.001). The affinity of GC forGR and the level of cortisol were not significantly different in the 2 groups. We suggest that the maturation of GR could be delayed in HMD. In the second part of the work we demonstrated in vitro that Phorbol mirystate acetate increased significantly the number of GR. This could be a way to a new therapeutic approach in the prevention of HMD.
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Storme, L., Formstecher, P., Dautrevaux, M. et al. 183 Deficiency of glucocorticoids receptors (GR) in Hyaline Membrane Disease (HMD) preliminary results. Pediatr Res 28, 307 (1990). https://doi.org/10.1203/00006450-199009000-00207
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DOI: https://doi.org/10.1203/00006450-199009000-00207
