Abstract
Cerebral blood flow velocities (CBFV) were measured by pulsed Doppler in 16 infants, 26 to 29 weeks gestation, involved in the Exosurf European Trial whose end point was survival without brain lesions. They were randomized to a blinded dose of air or Exosurf, if intubated within the first 2h, with a 2nd dose 18h later. If a respiratory distress syndrom occured, they received 2 rescue doses of Exosurf 12h apart. The area under the curve (Vmean), the Resistance Index (RI= (Vsyst-Vdiast)/Vsyst), and the Pulsatility Index (PI=(Vsvst-Vdiast)/Vmean) were recorded at the siphon of the internal carotid artery 15-30 min before and after each blinded dose, or unblinded Exosurf. Ventilator settings, blood pressure and gases were not different. RESULTS (Mean+Std):
We conclude that Exosurf administration does not modify CBFV within the conditions of the protocol.
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Hascoët, J., Hamon, I., Santos, E. et al. 24 EFFECT OF SURFACTANT ADMINISTRATION ON CEREBRAL CIRCULATION. Pediatr Res 30, 632 (1991). https://doi.org/10.1203/00006450-199112000-00054
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DOI: https://doi.org/10.1203/00006450-199112000-00054
